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pentobarbital will decrease the level or effect of brexpiprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Double brexpiprazole quota over 1-2 weeks if administered with a strong CYP3A4 inducer.pentobarbital will decrease the level or effect of larotrectinib by affecting hepatic/intestinal enzyme CYP3